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Decellularized extracellular matrix mediates tissue construction and regeneration
《医学前沿(英文)》 2022年 第16卷 第1期 页码 56-82 doi: 10.1007/s11684-021-0900-3
关键词: decellularized extracellular matrix 3D culture organoids tissue repair
Stem cell niches and endogenous electric fields in tissue repair
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 40-44 doi: 10.1007/s11684-011-0108-z
Adult stem cells are responsible for homeostasis and repair of many tissues. Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, which is recognized to have an important role in regulating tissue maintenance and repair. In wound healing and tissue repair, stem cells are mobilized and recruited to the site of wound, and participate in the repair process. Many regulatory factors are involved in the stem cell-based repair process, including stem cell niches and endogenous wound electric fields, which are present at wound tissues and proved to be important in guiding wound healing. Here we briefly review the role of stem cell niches and endogenous electric fields in tissue repair, and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
付小兵
《中国工程科学》 2009年 第11卷 第10期 页码 122-128
组织再生是21世纪生物学和医学领域研究的重点和热点。在回顾再生医学研究历史的基础上,概要介绍了组织再生所涉及的关键科学问题、重大需求以及部分已经取得的重要进展,并对将来的发展进行了展望。
生物材料在心脏修复和再生中的应用 Review
Zhi Cui,Baofeng Yang,Ren-Ke Li
《工程(英文)》 2016年 第2卷 第1期 页码 141-148 doi: 10.1016/J.ENG.2016.01.028
心血管疾病是全世界主要致死原因之一。人们对新的干预性治疗手段的需求与日俱增。虽然药物和手术治疗极大地改善了心血管疾病患者的生活质量,但人们还是需要价格更便宜、副作用更小的治疗手段。天然和合成生物材料无论是作为给药载体,还是替代支架的细胞外基质,在心脏修复和再生中都展现出巨大的潜力。本文探讨了目前治疗心血管疾病的几种方式和应用于上述疾病干预性治疗的生物材料;着重研究了导电聚合物在纠正局部缺血性心脏病引发的传导异常及其在心脏起搏器中应用的可能性,以改善心肌梗死状态下的传导路径。
Generation and repair of AID-initiated DNA lesions in B lymphocytes
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 201-216 doi: 10.1007/s11684-014-0324-4
Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.
关键词: class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability
Bile duct injury repair — earlier is not better
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 508-511 doi: 10.1007/s11684-015-0418-7
Bile duct injury is a common complication of cholecystectomy. The timing of bile duct injury repair remains controversial. A recent review conducted in France reported 39% complications and 64% failure after immediate repair in 194 patients compared with 14% complications and 8% failure after late repair in 133 patients. A national review of 139 consecutive early repairs conducted at five hepatopancreaticobiliary centers in Denmark reported 4% mortality, 36% morbidity, and 42 restrictures (30%) at a median follow-up of 102 months, and only 64 patients (46%) demonstrated uneventful short-term and long-term outcomes. Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommended. Percutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak because they convert acute bile duct injury into a controlled external biliary fistula. The ensuing benign biliary stricture should be repaired by a biliary surgeon after a delay of 4–6 weeks once the external biliary fistula has closed.
关键词: bile duct injury cholecystectomy laparoscopic cholecystectomy
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Progress and perspectives of neural tissue engineering
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 401-411 doi: 10.1007/s11684-015-0415-x
Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
《医学前沿(英文)》 2007年 第1卷 第1期 页码 6-10 doi: 10.1007/s11684-007-0002-x
关键词: available observable neuroregeneration protection function reconstruction
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 112-116 doi: 10.1007/s11684-010-0016-7
关键词: cervical cancer radical surgery peritoneum subcutaneous tissue
Primary cilia in hard tissue development and diseases
《医学前沿(英文)》 2021年 第15卷 第5期 页码 657-678 doi: 10.1007/s11684-021-0829-6
关键词: primary cilia bone mechanical sensing hard tissue cilium-related bone disease tooth
Mobile platform for hydraulic turbine blade repair robot
GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang
《机械工程前沿(英文)》 2008年 第3卷 第2期 页码 164-169 doi: 10.1007/s11465-008-0035-0
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
《医学前沿(英文)》 2019年 第13卷 第6期 页码 730-740 doi: 10.1007/s11684-019-0687-7
关键词: upper tract urothelial carcinoma GATA binding protein 3 mismatch repair microsatellite instability prognosis
Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 338-345 doi: 10.1007/s11709-017-0411-0
关键词: Calcium Sulfoaluminate (CSA) cement Type III cement coefficient of thermal expansion (CTE) shrinkage rapid repair
Microorganism-derived biological macromolecules for tissue engineering
《医学前沿(英文)》 2022年 第16卷 第3期 页码 358-377 doi: 10.1007/s11684-021-0903-0
关键词: biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate
标题 作者 时间 类型 操作
Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled
Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,
期刊论文
Mobile platform for hydraulic turbine blade repair robot
GUI Zhongcheng, CHEN Qiang, SUN Zhenguo, ZHANG Wenzeng, LIU Kang
期刊论文
Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma
Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He
期刊论文
Experimental study and field application of calcium sulfoaluminate cement for rapid repair of concrete
Yanhua GUAN, Ying GAO, Renjuan SUN, Moon C. WON, Zhi GE
期刊论文